A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model.
نویسندگان
چکیده
The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 52 11 شماره
صفحات -
تاریخ انتشار 2016